Opportunistic genetic screening based on MGP-NGS in patients with suspicion of hereditary cancer reveals these incidental findings (IFs). Methods MGP-NGS was performed in patients who fulfilled the ...

Patients with stages I to III breast cancer who were seen at a single cancer center between 2010 and 2012, and who agreed to participate in research DNA banking, were included (N = 488). Personal and ...

Nevertheless, 3 of the 8 patients (37.5%) displayed MSI-H by NGS, which revealed truncating mutations in the MSH6 gene in exon 4 in 62.5% (5/8) of the patients, including nonsense mutations (37.5%), ...

Researchers in the lab of Hans-Peter Kiem, MD, PhD, at Fred Hutch Cancer Center have devised a method that could one day treat genetic hematologic disorders by correcting how the body makes blood ...

3Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, Massachusetts. 4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Geoff Bennett: Doctors at the Children's Hospital of Philadelphia told them that their son had a rare genetic disease known as CPS1. It only affects one in 1.3 million babies, but the disease ...

News broke yesterday that researchers in Philadelphia appear to have successfully treated a 6-month-old baby boy, called KJ, with a personalized CRISPR gene-editing therapy. The treatment corrects ...

The treatment, described in a new study published in The New England Journal of Medicine and presented at the American Society of Gene and Cell Therapy meeting, relies on a complex therapy known ...

This baby boy was treated with the first personalized gene-editing drug Doctors say they constructed a bespoke gene-editing treatment in less than seven months and used it to treat a baby with a ...

Those delivered the gene-editing treatment, wrapped in fatty lipid molecules to protect it on its way to the liver. The therapy targets the exact DNA mutation that needs to be changed, instructing ...

A baby born with a rare and dangerous genetic disease is growing and thriving after getting an experimental gene editing treatment made just for him. Researchers described the case in a new ...

For the first time, doctors have treated a baby born with a rare, life-threatening genetic disorder with a gene-editing therapy scientists tailored to specifically repair his unique mutation.