Background: A common missense variant of the CDKN2A gene (A148T) predisposes to malignant melanoma in Poland. An association between malignant melanoma and breast cancer has been reported in several ...
p16 Ink4a+, encoded by CDK 2a (Cdkn2a), is a widely recognized marker of cellular senescence, crucial in processes like aging and disease. A fluorescence-based reporter line called p16-tdTomato ...
Dr. Cassidy leads the group’s work on melanoma chemoprevention. The Leachman-Cassidy group was the first to report on the role of CDKN2A/p16 in the oxidative stress pathway in melanocytes, creating a ...
no systematic study has been conducted on p16 expression in melanocytic tumors from patients carrying germline CDKN2A mutations. We analyzed 98 early primary lesions from familial patients, previously ...
Introduction One of the commonest genetic abnormalities in malignant mesothelioma is deletion of the 9p21 locus which harbours the p16/CDKN2A gene. Homozygous deletion of p16/CDKN2A can be identified ...
Immunohistochemistry validation was carried out for further detection. The results showed that CDKN2A and MTF1 were cuproptosis-associated differential genes in LUAD, with differential expression ...
Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute, New South Wales, 2145, Australia CDKN2A germline mutations are rare and many only underlie melanoma ...
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