Here, the authors identify an O-glycosylation program and glycosylated Calnexin in synovium’s edge fibroblasts as drivers of extracellular matrix degradation, highlighting potential therapeutic ...

Here, the authors identify an O-glycosylation program and glycosylated Calnexin in synovium’s edge fibroblasts as drivers of extracellular matrix degradation, highlighting potential therapeutic ...

Post parturition period during which female animal does not exhibit estrus behavior and is unable to get successfully fertilized and conceive is known as post-partum anestrus. It causes buffalo ...

Polyphosphate (polyP) exists in all life forms; however, its biological functions in metazoans are understudied. Here, we explored Drosophila as the first genetic model to explore polyP biology in ...

Heart failure (HF) is recognized as an epidemic in the contemporary world, impacting around 1%–2% of the adult population and affecting around 6 million Americans. HF remains a major cause of ...

Gaucher disease (GD) is an inherited disorder caused by recessive mutations in the GBA1 gene that encodes the lysosomal enzyme β-glucocerebrosidase (β-GC). β-GC hydrolyzes glucosylceramide (GluCer) ...

TFEB overexpression or pharmacological activation of TFEB ameliorates cholesterol accumulation in U18666A-induced HeLa NPC1 model. A working scheme to illustrate that small-molecule TFEB agonist ...