Peptide-drug conjugates (PDCs) are emerging as a promising alternative to antibody-drug conjugates (ADCs), offering enhanced tumor penetration and reduced immunogenicity. Carbonic anhydrase IX (CAIX) ...

Comparisons of the predicted protein sequences allowed their classification based on conserved regions of carbonic anhydrase, as follows: CAs signature; Zn binding amino acids and highly conserved ...

STARLITE 2: Phase 2 study of nivolumab plus 177Lutetium-labeled anti-carbonic anhydrase IX (CAIX) monoclonal antibody girentuximab (177Lu-girentuximab) in patients (pts) with advanced clear cell renal ...

Human carbonic anhydrases (hCAs) have been recognized as suitable drug targets for this therapeutic approach. These enzymes play a key role in maintaining pH balance, ion transport, and fluid ...

Always check with a healthcare provider before taking a supplement. The medicine works by limiting an enzyme called carbonic anhydrase. This is an enzyme in the kidney that puts minerals, sodium, and ...

Contributed by Krishna K. Niyogi, March 14, 2017 (sent for review January 4, 2017; reviewed by Howard Griffiths and Donald P. Weeks) Algae harboring secondary plastids of red algal origin constitute ...

Some commonly prescribed combination medications include: Combigan (beta blocker and alpha agonist) Cosopt (beta blocker and carbonic anhydrase inhibitor) Rocklatan (rho kinase inhibitor and ...

How does acetazolamide work (mechanism of action)? Acetazolamide blocks an enzyme called carbonic anhydrase in the body. This helps lower pressure inside the eye, increases how much you pee to ...

These drugs reduce the activity of an enzyme in the kidneys called carbonic anhydrase. They prevent the reabsorption of bicarbonate, making the urine more alkaline (basic). Too much bicarbonate in ...

Researchers from Peptidream Inc. presented preclinical characterization of novel carbonic anhydrase IX (CAIX)-targeting radiopeptides, [64Cu]PD-32766 and [177Lu]PD-32766, being developed for the ...