GlobalData on MSN2d
FDA expands Enhertu approval to include HER2-ultralow breast cancer patients
AstraZeneca and Daiichi Sankyo’s antibody-drug conjugate (ADC) Enhertu (trastuzumab deruxtecan) has received approval from ...
Cancer Therapy Advisor3d
Enhertu Approved for HR+, HER2-Low/Ultralow Metastatic Breast Cancer
The FDA has approved Enhertu (fam-trastuzumab deruxtecan-nxki) for HR-positive, HER2-low or HER2-ultralow metastatic breast cancer.
PharmiWeb3d
Enhertu approved in the US as first HER2-directed…
AstraZeneca and Daiichi Sankyo’s Enhertu (trastuzumab deruxtecan) has been approved in the US for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, ...
eLife3d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...
High-speed microscopy technique reveals dynamic E. coli membrane stiffness
Light and electron microscopy have distinct limitations. Light microscopy makes it difficult to resolve smaller and smaller ...
Inside the Cell: Breakthrough Microscopy Exposes the Hidden Teamwork of Ribosomes
A new imaging technique reveals ribosomes work together when translating mRNA, preventing slowdowns in protein production. This discovery challenges prior beliefs and could revolutionize our ...
New light-tuned chemical tools control processes in living cells
A research group at Umeå University has developed new advanced light-controlled tools that enable precise control of proteins ...
News Medical on MSN1d
High-speed in-line force mapping unveils E. coli cell division dynamics
Light and electron microscopy have distinct limitations. Light microscopy makes it difficult to resolve smaller and smaller features, and electron microscopy resolves small structures, but samples ...
eLife3d
Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer
This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...
Nature6d
Membrane biophysics articles from across Nature Portfolio
Membrane biophysics is the study of the physical ... and the effect they have on paracellular transport and phenomena relating to cell shape. The mechanism of RCD-1 regulated cell death in fungal ...
BMJ4d
Immunopathology of psoriasis and psoriatic arthritis
Moreover, staining of adjacent inflamed PsA synovium with antibodies to RANKL revealed intense expression by the synovial lining cells, while osteoprotegerin staining was relatively faint and limited ...
Yahoo Finance6d
AstraZeneca PLC (AZN)
WILMINGTON, Del., December 05, 2024--AstraZeneca’s IMFINZI® (durvalumab) has been approved in the US for the treatment of adult patients with limited-stage small cell lung cancer (LS-SCLC ...