For most of us, getting less than seven hours of sleep translates into grogginess, sluggish thinking, and an overwhelming ...

Conclusions FSTL1 is a potent regulator of chondrocyte proliferation, differentiation and expression of ECM molecules. Our findings may lead to the development of novel strategies for cartilage repair ...

Methods High throughput screening of 170 000 compounds identified a small molecule gp130 modulator termed regulator of cartilage growth and differentiation (RCGD ... RCGD 423 greatly reduced ...

Sulfated glycosaminoglycans (GAGs), which are found in the native extracellular matrix, are known to interact with growth factors and, thus, promote chondrocyte function ... pSC and SS enhanced MSC ...

chondrogenic differentiation of MSCs and chondrocyte-to-osteoblast transdifferentiation also play important roles in endochondral ossification and can both be regulated by many of the same types of ...

rather than direct chondrocyte transformation, is supported by the observation that in vitro coculture of MSCs with chondrocytes results in upregulation of collagen matrix formation, despite only ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

The development of multicellular organisms and the maintenance of homeostasis in adulthood are achieved by complex control of basic cellular processes such as the maintenance of pluripotent stem cells ...

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