Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders ...

The results of this study will indicate if a growth environment enhanced with the SCM and bFGF will lead to increased human chondrocyte proliferation while maintaining differentiation potential.

1 Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Zhejiang, China Objectives Epigenetic mechanisms have been reported to play key ...

Objectives To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular ...

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Figure 1. Chondrocytes originate from MSCs and undergo a series of differentiation processes. Sox9 induces MSCs differentiate into chndrocytes and promotes proliferation, whereas Runx2 stimulates ...

The profiled open chromatin regions recapitulate known chondrocyte and skeletal biology, are enriched at height GWAS loci, particularly near differentially expressed growth plate genes, and enriched ...