c) For the inverted duplications, the ideograms and partial karyotypes of two chromosome 15s show the two different sizes of inv dup (15) chromosomes. The smaller inv dup (15), on the left ...

It is generally assumed that the basic genetic material is DNA (deoxyribonucleic acid). How are the molecules of DNA arranged in the chromosome, and how do they make replicas of themselves?

For instance, deletions that span a centromere result in an acentric chromosome that will most likely be lost during cell division. As with duplications, deletions can affect gene dosage and thus ...

A genetic evaluation demonstrated Klinefelter syndrome 47, XXY karyotype with concurrent duplication of 3p21.31 by microarray analysis. Maternal genetic analysis demonstrated the same 3p21.31 ...

Scott W. Stuart, MD, MS; Casey H. King, BA; G. Shashidar Pai, MD Such observations emphasize the importance of clarifying the origin of a genetic variation by studying the parents for comparison ...