and sometimes there were parts of chromosomes on their own, in one or multiple copies. The phenomenon that produces such genomic chaos is known as chromosomal instability (CIN). Cancer researchers and ...

Chromosomal instability (CIN) is a significant characteristic of many cancers, marked by the presence of large-scale changes in the number and structure of chromosomes. This instability can lead ...

Chromosome instability describes the increased probability of acquiring chromosomal aberrations due to defects in processes such as DNA repair, replication or chromosome segregation. NLRP7 plays ...

In particular, they could open new doors for preventing or treating diseases caused by chromosome instability, a factor in genetic disorders such as cancer and Down syndrome. In a related study ...

During this time she again did important work, such as discovering the breakage-fusion-bridge (BFB) cycle, a source of chromosome instability which is still important in cancer research today.

Moreover, their findings revealed that such damage can trigger rearrangements of chromosomes—hallmarks ... linked to a high degree of chromosomal instability," said Professor Gary Ying Wai ...

This study details the design and optimization of synXVI, a synthetic yeast chromosome, overcoming growth challenges through ...

Accordingly, defects in chromosome replication are a major driver of the genomic instability observed in cancer cells. To understand the molecular mechanisms by which eukaryotic cells carry out and ...

Moreover, their findings revealed that such damage can trigger rearrangements of chromosomes -- hallmarks ... linked to a high degree of chromosomal instability," said Professor Gary Ying Wai ...