Genetic instability in the form of mutations and chromosome rearrangements is usually associated with pathological disorders, but it is also crucial for evolution and the generation of genetic ...

and sometimes there were parts of chromosomes on their own, in one or multiple copies. The phenomenon that produces such genomic chaos is known as chromosomal instability (CIN). Cancer researchers and ...

Second, we have shown that mutations of the NBS1 and MRE11 genes, encoding members of the human complex, are responsible for the chromosome instability syndromes — Nijmegen breakage syndrome (NBS) and ...

Dr Tatini Rakshit, Assistant Professor, Department of Chemistry, School of Natural Sciences, Shiv Nadar University, highlights how innovative approaches like chromosome analysis and AFM could signific ...

They exist as circular pieces of DNA in the nuclei of tumor cells outside chromosomes ... and also promote the evolution of genome instability and resistance to therapy. Complex DNA-breakage ...