Oxysterols are a class of molecules derived from cholesterol via oxidation or as byproducts of cholesterol synthesis. Despite ...

In an article published in the journal Trends in Biochemical Sciences, Alicia Kowaltowski, full professor at the University ...

There is therefore interest in developing drugs that lower cortisol by targeting its endocrine pathway, the hypothalamic–pituitary ... We propose CRH-neutralizing antibodies and CRH-synthesis ...

Additionally, the expression of genes associated with E2, cortisol, 5- HT, and DA pathways was relevantly altered ... responses possibly by modulating plasma cortisol levels and the synthesis and ...

This means that Xanamem is a unique orally administered molecule in its own class as a ’tissue cortisol synthesis inhibitor’ and it is the first drug to be named by the WHO in that class. Dr Steven ...

This means that Xanamem is a unique orally administered molecule in its own class as a 'tissue cortisol synthesis inhibitor' and it is the first drug to be named by the WHO in that class.

The new move recognises Xanamem as the first drug named in its class of enzyme inhibitors targeting cortisol synthesis in the brain. It is a huge milestone for the firm as few Australian-developed ...

Cortisol is a hormone that is made in the adrenal glands, which are located next to the kidneys. Cortisol is used by the body for several reasons, including fighting infections, mounting a stress ...

Mechanistically, we found that PGAM regulates Treg differentiation by controlling flux through the de novo serine synthesis pathway. The PGAM substrate 3PG is also utilized for serine synthesis, and ...

Overall, digital pathways in education and skills development can be seen as the interplay of two dimensions: (1) depth of digital transitions, the extent to which public policy efforts take a ...

Systolic blood pressure (A) and salivary cortisol (B) did not differ between groups before or immediately after the Memory Cueing task. However, 70 minutes after pill intake, systolic blood pressure ...