Cells use many complex genetic repair backup systems to fix DNA damage and remain healthy throughout their lives.

Researchers harness the power of the world’s most advanced supercomputers to simulate the inner workings of cellular machinery that repairs DNA and helps prevent life-threatening diseases. Sunburn and ...

DNA damage and repair refers to the creation ... DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection ...

Researchers from the University of Birmingham have uncovered answers that provide the detail to explain two specific DNA repair processes that have long been in question. The publication of two papers ...

The DNA of human cells consists of a sequence of about ... Only when the backup is also switched off do they lose the ability ...

The double ring, spool-like structure of RAD52 protects replicating DNA in dividing cells. A study led by the University of ...

Damage to the mitochondria, the 'power plants' of the cells, contributes to many diseases. Researchers now describe how cells with defective mitochondria activate a special recycling system to ...

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and ...

Mutations in BRCA2—a gene known to repair damaged DNA and suppress tumor ... maintaining the integrity and function of DNA repair pathways. "Cancer cells can somehow tolerate the loss of the ...

A study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP inhibitors.

Study reveals alpha-synuclein's role in enhancing DNA repair in melanoma, linking Parkinson's protein to cancer cell survival ...