Abacavir functions as HIV-1 reverse transcriptase (RT) and is produced in cells by cellular enzymes as carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir ...
Institute of Pharmaceutical Analysis, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China ...
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Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. In this study, for the first time, we thoroughly validated the ...
Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin–angiotensin system (RAS) is involved in the regulation of ...
16Deficiency of ADA results in the accumulation of dAdo and deoxyadenosine triphosphate (dATP). Raised dAdo directly inactivates the enzyme S-adenosylhomocysteine hydrolase (SAH hydrolase)17 which is ...
Taken together, in vitro as well as in vivo experiments in several follicular cell-derived and medullary thyroid cancer cell lines have clearly demonstrated a therapeutic effect of the HSV-tk/GCV ...