Randomised controlled trials (RCT), or randomised clinical trials, are experimental studies where the effect of an intervention is assessed by collecting data before and after an intervention has ...

What is a randomized controlled trial? Randomized controlled trials are the “gold standard” for testing the safety and efficacy of drugs and treatments on the market.

Relevant trial designs that have been developed and utilized include phase II selection designs, randomized phase II designs that include a reference standard-treatment control arm, and phase II/III ...

A few randomized trials of closed-loop systems in an outpatient setting have been conducted in this age range with a similar number of participants and trial duration (>1 month).

In response to recent Medicare calls for increased evaluation of obesity treatments, an FDA meeting on open questions in the conduct of obesity treatment trials, and high profile editorials in general ...

In this review, the authors consider the characteristics and challenges of noninferiority trial designs, including seven essential features of noninferiority trials.

A randomized control trial, or RCT, is a powerful way to design experiments to identify causal effects of an intervention. In an RCT, participants are randomly selected into treatment and control ...

Randomized clinical food trials are essential to this task, for which data management and quality management are synonymous with best clinical practice.

The LEADERS trial enrolled 1,707 patients in 10 European hospitals between November 2006 and May 2007, while RESOLUTE-III enrolled 2,292 patients at 19 European hospitals between May and October 2008.

The current randomized waitlist controlled trial sought to determine the efficacy of cognitive behavioral therapy for insomnia (CBT-I) on subjective CRCI among a heterogeneous sample of cancer ...

WHAT ARE THE NEW FINDINGS? This large-scale systematic review and network meta-analysis of 270 randomised controlled trials demonstrates the optimal exercise prescription practices in the management ...