Normally, TDP-43 mostly operates in the nucleus, binding RNA to guide splicing and ... Chief among them were the PIAS E3 ligases (also identified by Carra’s group, see below) and the SUMO-targeted ...

RT-qPCR was conducted to determine the mRNA expression levels of E3 ligase candidates. The si-RNA targeting regions for the candidate E3 ubiquitin ligase proteins and the targeted regions for RT-qPCR ...

An accumulating body of work found that ubiquitylation of histones, transcription factors, or RNA polymerase II is crucial for ensuring that transcription occurs at the right time and place during ...

Get Instant Summarized Text (Gist) A new biochemical method enables mapping of RNA folding as it occurs in living cells, revealing that RNA molecules begin folding immediately during synthesis ...

Bristol Myers Squibb Co. has disclosed proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) E3 ubiquitin ligase-binding moiety covalently bonded to a B-cell lymphoma 6 protein ...