Translation initiation (see figure) requires the association of the eukaryotic translation initiation factor-4F (eIF4F) complex (which consists of the cap-binding factor eIF4E (4E in figure), the ...

Creative Diagnostics, a leading manufacturer and supplier of antibodies, antigens and assay kits, has announced its ...

Ribosome attachment and scanning are impeded by structures in the 5′ UTR that can be resolved by RNA helicases Ded1 and eukaryotic translation initiation factor 4A (eIF4A), with cofactors eIF4B and ...

The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in the control of cell growth. eIF4E binds to the mRNA 5′ cap structure m 7 GpppN (where N is any nucleotide), and ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

suggesting a positive role of eS26 in leaderless mRNAs translation and possible evolutionary routes from archaeal to eukaryotic translation. This Review summarizes key events in the emergence of ...

Several genetic studies have attempted to explore the fungal factors involved in antiviral responses, but the exact genes and ...

Scanning of the mRNA transcript by the preinitiation complex (PIC) requires a panel of eukaryotic initiation factors, which includes eIF1 and eIF1A, the main transducers of stringent AUG selection.

Department of Cellular and Molecular Pharmacology and Physiology (M.S., B.C.B.), University of Rochester School of Medicine and Dentistry, NY. Department of Medicine ...

The authors present an important set of data implicating ETFDH as an epigenetically suppressed gene in cancer with tumor suppressive functions. The evidence is solid, with the authors demonstrating ...

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