Recent work by Senti et al (2025) reports that retrotransposons and endogenous retroviruses occupy specific spatiotemporal ...

Northwestern Medicine scientists have uncovered new details about how poxvirus hijacks its host's protein synthesis machinery ...

Scanning of the mRNA transcript by the preinitiation complex (PIC) requires a panel of eukaryotic initiation factors, which includes eIF1 and eIF1A, the main transducers of stringent AUG selection.

Translation initiation (see figure) requires the association of the eukaryotic translation initiation factor-4F (eIF4F) complex (which consists of the cap-binding factor eIF4E (4E in figure), the ...

Ribosome attachment and scanning are impeded by structures in the 5′ UTR that can be resolved by RNA helicases Ded1 and eukaryotic translation initiation factor 4A (eIF4A), with cofactors eIF4B and ...

To our knowledge, this is the first report conclusively identifying in vivo D/E-methylation substrates and their modification sites in eukaryotic cells, demonstrating that D/E-methylations are ...

The eukaryotic translation initiation factor eIF1A is frequently mutated in cancer and binds the 40S ribosome via a direct interaction with the RPS10 protein. Here, a high throughput screen identifies ...

Department of Cellular and Molecular Pharmacology and Physiology (M.S., B.C.B.), University of Rochester School of Medicine and Dentistry, NY. Department of Medicine ...