Then, the team developed a mouse model of AFib in which the gene Fkbp5 was absent only in heart cells, called cardiomyocytes. "These Fkbp5-deficient mice had an increased susceptibility to AFib ...

The FKBP5 gene encodes FKBP prolyl isomerase 5, a co-chaperone that modulates glucocorticoid signaling and that is expressed in T cells, neurons and in microglial cells in the central nervous system ...

In our recent study, we discovered that which genetic variant of the FKBP5 gene a person carries is predictive of how much post-traumatic chronic pain an individual will experience following motor ...

Reduced levels of FKBP5 promote atrial fibrillation. Baylor College of Medicine. Journal Circulation Research DOI 10.1161/CIRCRESAHA.122.322213 ...

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus. International Journal of Molecular Sciences , 2019; 20 (11 ...

High FKBP5 normally decreases AKT signaling, but when early life stress was added to overexpressed FKBP5 that signaling activity increased," Dr. Blair said. "Overall, ...

High FKBP5 normally decreases AKT signaling, but when early life stress was added to overexpressed FKBP5 that signaling activity increased," Dr. Blair said. "Overall, ...

Cruz B, Vozella V, Carper BA et al. FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder.