The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

Specifically, knockdown of LKB1 increased the mRNA level of focal adhesion kinase (FAK) and vice versa in LKB1-overexpressed cells, a key component of the activated focal adhesion pathway.

Primary antibodies were used at a 1:200 dilution: p-Y-576/p-Y-577–FAK (focal adhesion kinase) (Cell Signaling, Boston, MA); FAK, actin, PECAM-1, β-catenin (Santa Cruz, Santa Cruz, CA ...

Notable updates occurred in December 2024 for investigational products in development. The table below is a review of notable updates that occurred in December 2024 for investigational products in ...

Defactinib is an oral, selective inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (Pyk2), the two members of the focal adhesion kinase family of non-receptor protein ...

A randomized phase II clinical trial evaluating the safety and efficacy of initial dose adjustment of zolbetuximab plus chemotherapy in patients with HER2-negative and CLDN18.2-positive unresectable ...

FIGURE 3. Targeting adhesion molecules in melanoma anoikis resistance. A range of integrins, as well as N-cadherin, and their downstream signalling pathways, including FAK (green), Mitogen-Activated ...

However, the study provides limited new insights into the relationship between retinal lamination defects and overall retinal function. Neural lamination is a common feature of the central nervous ...

In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...

People with Crohn’s disease who have had a previous abdominal surgery may be more prone to developing adhesions. Adhesions can also develop from an abscess or fistula. Internal organs normally ...

Labial adhesions happen when the labia minora (the inner folds of skin surrounding the vaginal opening) become fused together. In most cases, only a small part of the labia is fused, so the adhesions ...