Alendronate (as sodium), cholecalciferol (Vit ... For patients at low-risk for fracture, consider drug discontinuation after 3–5yrs. Swallow whole. Take in the AM with plain (not mineral ...

Release of the drug from the bone mineral matrix requires bone resorption, and reduction in bone resorption is the primary mode of action of bisphosphonates. The terminal half-life of alendronate ...

Alendronate (Fosamax, Fosamax Plus D, and generic), the first bisphosphonate approved by the Food and Drug Administration for the treatment and prevention of osteoporosis, came on the market in ...