Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders, such as craniosynostosis and chondrodysplasia, which severely affect ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...

Oxysterols are a class of molecules derived from cholesterol via oxidation or as byproducts of cholesterol synthesis.

A European research collaboration has found that besides regulating the fusion of mitochondria, Mitofusin 2 also ensures protein quality control. This discovery could open up new routes to treating Ch ...

A team of researchers from the Sant Pau Research Institute (IR Sant Pau) has published a study in the Journal of ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, P. R. China Trauma Medical Center, Department of Orthopedics Surgery, West ...

In today’s fast-paced world, joint pain has become a common concern among individuals of all ages, significantly impacting quality of life and overall well-being. Many struggle with everyday ...

We demonstrated that LNA-miR-181a-5p ASO in rat and mouse chondrocytes reduced the expression of cartilage catabolic and chondrocyte apoptotic/cell death markers in vitro. Treatment of OA-induced rat ...

Conclusions These findings indicate that knockdown of Kdm6b in chondrocytes leads to abnormal cartilage development and accelerated OA progression via inhibition of the anabolic metabolism of ...

Most neurons that carry signals regarding movement and higher-level functions, such as thinking and reading, are myelinated. Neurons that control feelings of pain and temperature are sometimes ...

For example, the left or right side may be slightly higher or lower without affecting physical functions. During pregnancy, a woman's enlarged uterus can shift the abdominal space a bit, raising the ...