Aspergillus ... Antifungal drugs target molecules in the fungal cell wall, a flexible but rigid outer layer that provides the cell protection. By rupturing the protective structure, the drugs ...

Human fungal pathogens exemplify a severe threat to health due to their complex infection strategies and the host's immune system's failure to eradicate ...

Bacterial cells close bacterial cell A microscopic individual cell of a bacterium. have a more simple structure compared to animal, plant and fungal cells and are usually much smaller.

Evidence for resistance is growing Several antifungal resistance mechanisms are now known, including: drug efflux, alterations in drug targets, changes in cell membrane and lipid composition ...

In addition, Candida species cause a variety of mucosal and superficial skin infections that affect many people. Until recent years, the armamentarium of antifungal agents for management of IFDs ...

Of critical importance are Candida albicans and auris, Aspergillus ... issue is that antifungal drug development takes a long time and is very expensive. Fungal and human cells are more similar ...

Azole medicines are essential for treating aspergillosis, a serious infection caused by Aspergillus fungi. However, these fungi are increasingly becoming resistant to azole therapies, making treatment ...

Evidence for resistance is growing Several antifungal resistance mechanisms are now known, including: drug efflux, alterations in drug targets, changes in cell membrane and lipid composition ...