eLife6d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...
Cancer Research19d
An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer
1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...
The EMBO Journal28d
RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Small GTPase RHEB is a well-known mTORC1 ...
The EMBO Journal28d
Two FAM134B isoforms differentially regulate ER dynamics during myogenesis
FAM134B2 lacks the first hairpin structure of the reticulon homology domain but retains the LC3-interacting region (LIR) domain, enabling it to function as an ER-phagy receptor. Proper ER membrane ...
Frontiers29d
Sulforaphane acutely activates multiple starvation response pathways
GFP-LC3, mito-RoGFP, mtKeima, LTR, and MTG/TMRE flow cytometry were done as described (25), and FlowJo 10.3 software was used for gating analysis and quantification for all flow cytometry studies.