Taking Drugs for Erectile Dysfunction? Do These 5 Things to Get More Bang for Your Buck
Medications to treat ED are exceedingly popular, with sildenafil (sold under the more commonly known brand name Viagra) being ...
Daily4d
Dr Reddys Gets CDSCO Panel Nod To Manufacture, Market Linaclotide Capsules for Chronic Idiopathic Constipation
New Delhi: Pharmaceutical major Dr Reddy's has got approval from the Subject Expert Committee (SEC) functional under the ...
BMJ6d
Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling
Methods Human fibroblasts and murine sGC knockout fibroblasts were treated with the sGC stimulator BAY 41-2272 or the stable cyclic guanosine monophosphate (cGMP) analogue 8-Bromo-cGMP and stimulated ...
Frontiers5d
Heart Failure With Preserved Ejection Fraction: A Review of Cardiac and Noncardiac Pathophysiology
There, NO activates soluble guanylyl cyclase (sGC) and its second messenger cyclic guanosine monophosphate (cGMP), producing relaxation of the vascular smooth muscles and widening of the blood vessel ...
Nature5d
Breaking the chains: structure and function of the deubiquitinases
Ubiquitylation is a reversible post-translational modification involved in a myriad of cellular functions. A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating ...
C&EN5d
Acid-Cleavable Guanosine Triphosphate-Photoaffinity Probe for Global Profiling of Guanosine Triphosphate-Binding Proteins and Their Active Sites
Institute of Pharmaceutical Analysis, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China ...
Frontiers5d
Role of angiotensin II in aging
Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin–angiotensin system (RAS) is involved in the regulation of ...