Conversely, USP11 removes ubiquitin chain from Beclin 1 ... a process particularly crucial during spermatogenesis (87). HDACs, including HDAC1, HDAC2, HDAC3, and HDAC8, are responsible for removing ...

In experimental models, activating FXR, inhibiting HDAC1 that enables YAP repressor function, or increasing the expression of a bile acid export protein (BSEP), all helped reduce liver damage and ...

Furthermore, the TXNIP and HDAC1 contribute to inflammasome activation, leading to increased Caspase-1 activity and the subsequent maturation of IL-1β and IL-18, promoting neuroinflammatory ...

Background IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A ...

The human PYHIN family proteins, including AIM2, IFI16, IFIX, and MNDA, which are crucial cytosolic nucleic acid sensors. These proteins share a common structural feature, including signature ...

Samples enriched for proteins were analyzed by mass spectrometry. Figure 2. MARCHF7 and UBR5 were identified as E3 ubiquitin ligases involves in nsp16 protein degradation. A. Knockdown of MARCHF7 or ...

Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fujian Medical University, Fuzhou, 350122, China ...

Edited by Ana Maria Cuervo, Albert Einstein College of Medicine, Bronx, NY; received June 7, 2024; accepted February 26, 2025 ...

Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York ...