Here we show that pharmacologic inhibition of heat shock protein 90 (HSP90) with a small-molecule inhibitor, NVP-AUY922 (AUY922), leads to rapid degradation of TYK2 and apoptosis in T-ALL cells.

We determined the structure and function of Heat Shock Protein 90 (Hsp90), a molecular chaperone which is critical for the growth and survival of cancer cells. We worked with partners to discover the ...

To test this, the researchers injected the Hsp90 inhibitor KU-32 into the spinal cord of mice prior to morphine treatment and then exposed the animals to the tail-flick test, an established pain model ...