have an IP3-binding core in their large cytosolic region. The channel domain contains six transmembrane domains (TMDs), and three loops are exposed to the ER lumen (26). The third luminal loop ...

The FDA has granted orphan drug designation to AISA-021, a fourth-generation calcium channel blocker, for the treatment of systemic sclerosis, according to a press release from Aisa Pharma.

How Should I Take Them? Calcium channel blockers should be taken with food or milk. Follow the label directions on how often to take it. The number of doses you take each day, the time allowed ...

What Are Calcium Channel Blockers? Calcium makes your heart and blood vessels work harder to pump. Calcium channel blockers work by slowing the movement of calcium into the cells of the heart and ...

The authors have provided solid evidence consistent with their hypothesis that zinc ions regulate Ca++ oscillations by directly modulating the gating of the IP3-R which is the main calcium channel ...

Adding diuretics rather than calcium channel blockers to renin-angiotensin-system-inhibitor (RASi) therapy may slow chronic kidney disease (CKD) progression while offering cardioprotection ...

Researchers discovered that the calcium channel ORAI1 controls astrocyte-mediated brain inflammation, preventing tissue damage and behavioral depression in mice. This finding offers potential for ...

ABSTRACT Large conductance calcium-activated potassium (BK) channels carry out many functions in the central nervous system. These channels open in response to increased cytosolic calcium ([Ca2+]cyt) ...

Calcium channel blockers may improve treatment for pancreatic cancer patients receiving gemcitabine-based chemotherapy, according to recent findings published in the Proceedings of the National ...

Towards the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared on the scene, and practically shut down the world for the next several months. Since then, a slow ...

Loss of IP3-receptor-mediated Ca 2+ release in mouse B cells ... In the current study, we found that CRAC-channel-mediated calcium signaling is enhanced in B cells from patients with LN. CRAC channel ...