Recent breakthroughs in understanding the prostaglandin D2 (PGD2) receptor 1 (DP1) are paving the way for innovative ...

Recently, a new class of therapeutics that disable the neonatal Fc receptor (FcRn), which protects IgG from degradation, has emerged to treat IgG-mediated autoimmune disease. 4,5 Here, we review ...

Among the many GPCRs, β-adrenergic receptors were used as the model system in many early studies to understand GPCR structure and function. The importance of β-adrenergic signaling in cardiovascular ...

Real-World Molecular Testing Rates and Patterns in Patients With Primary Advanced or Recurrent Endometrial Cancer in the United States This study suggests a previously unrecognized association between ...

IP3 interacts with its receptor IP3R on the endoplasmic reticulum membrane ... Therefore, it is necessary to resolve the structure of ZDHHCs to develop selective inhibitors of ZDHHCs. However, because ...

“Our proven GPCR structure-based drug discovery platform enabled us to rapidly advance ACCG-2671 as the lead amylin receptor agonist. We are now developing a series of amylin-based drug candidates ...

Using advanced imaging techniques and an engineered version of human GPR6 suitable for crystallization, researchers determined the receptor's structure in different states, including when it's ...

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo ...

Clinical trial results presented at the 2023 European Society of Medical Oncology (ESMO) annual meeting and at the 2023 San Antonio Breast Cancer Symposium (SABCS) combined with earlier reports from ...

This important interdisciplinary study substantially advances our understanding of the prolactin receptor interactions with the membrane ... we demonstrate the formation of a co-structure composed of ...