Bristol Myers Squibb Co. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising a cereblon (CRBN) E3 ubiquitin ligase-binding moiety coupled to a DNA-binding protein Ikaros (IKZF1 ...
Potential novel combinatory complexes are highlighted in black boxes and yellow font (e.g., CTCF/ETS composite elements and JUN/IKZF composite elements). This work was supported by the Division of ...
Bristol Myers Squibb Co. has identified new substituted oxazolone protein-nucleic acid degraders acting as DNA-binding protein Ikaros (IKZF1) and zinc finger protein Helios (IKZF2), Aiolos (IKZF3) and ...
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