Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...
This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...
In cancers, all translocations involving ALK produce fusion proteins with constitutive tyrosine kinase activity that in most cases derives from spontaneous dimerization induced by the different ...
Copyright 2025 The Associated Press. All Rights Reserved. Workers pack dumplings at a production line at a food factory in Suqian city in east China’s Jiangsu ...
However, the clinical efficacy of mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi ... to evaluate the relationship between MAP2K1 mutation class and clinical activity of MAPKi. We ...
Can physical activity extend the lifespans of older adults? A review article published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi ...
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