Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...

Bruton’s tyrosine kinase (BTK) is known to regulate multiple anti-apoptotic ... The primary antibodies against BTK (phospho Y223), Mcl-1, Bim and β-actin were purchased from Abcam Inc. (Cambridge, MA, ...

The Connectivity map approach identified AZ-628 as a potent RIP3 inhibitor whose inhibition of RIP3 kinase activity abolished OA pathogenesis ... phospho-Receptor-interacting protein kinase 1 (p-RIPK1 ...

Copyright 2025 The Associated Press. All Rights Reserved. Workers pack dumplings at a production line at a food factory in Suqian city in east China’s Jiangsu ...

However, the clinical efficacy of mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi ... to evaluate the relationship between MAP2K1 mutation class and clinical activity of MAPKi. We ...

Can physical activity extend the lifespans of older adults? A review article published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi ...

Story continues below this ad According to market participants, by launching the “when-listed” platform, SEBI wants to ensure some amount of pre-IPO activity to happen, but in a legal manner. The SEBI ...

So, how might you join in the festivities with your family this weekend? We have some fun activity ideas for you to try at home, with advice from Janet Cooper, a speech and language therapist ...

From within the major locus we found that normalization of gene dosage of the Dyrk1a (Dual-specificity tyrosine phosphorylation regulated kinase 1a) gene restored ... 1:100 (ab65220, Abcam); phospho ...

Here, we hypothesized that RIP1/RIP3 kinase activity are required for the development of high ... Plasma fractions were isolated using the plasma membrane protein extraction kit (ab65400, Abcam).

Do the work now and you’ll reap the rewards for years to come. Try to reserve this indoor activity for a picturesque snow day—you know, so you don’t end up spiking your blood sugar every day for five ...