AHA/ASA Journals11d
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...
The Lancet25d
Zika virus: advancing a priority research agenda for preparedness and response
dDepartment of Virology and Experimental Therapeutics, Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil eGonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz), Recife, Brazil fDepartment of ...
RiverBender.com26d
Tigers End Postseason Slump – Headed To Alton Regional Final Against Hosting Redbirds
The last time the Tigers held up the regional plaque was in 2016-17 under Mike Waldo. The No. 2-seeded Tigers got their wish and will play No. 3-seeded Alton Friday night in what should be an ...
Frontiers21d
Advances in the study of nicotinamide adenine dinucleotide phosphate oxidase in myocardial remodeling
Myocardial remodeling is a key pathophysiological basis of heart failure, which seriously threatens human health and causes a severe economic burden worldwide. During chronic stress, the heart ...
ahajournals.org21d
Targeting PAR4 to Reduce Atherosclerosis
Figure. Overview of current and in development antiplatelet agents. COX-1 indicates cyclooxygenase-1; GPVI, glycoprotein VI; PAR1, protease-activated receptor-1; PDE, phosphodiesterase; PDI, protein ...
BMJ24d
Efficacy and safety of abatacept, a T-cell modulator, in a randomised, double-blind, placebo-controlled, phase III study in psoriatic arthritis
Randomisation was stratified globally (rather than at site level) by factors that were considered to potentially impact results, including current methotrexate use, prior TNFi use and whether plaque ...
Frontiers21d
PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production
2.7 Plaque Assay to Determine Viral Titer in the CNS A virus plaque assay was performed as previously described (6) using virally susceptible BHK cells. Brain tissue was dissociated with a power ...
eLife27d
Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP
This manuscript addresses a mechanism by which dopamine (DA) regulates synaptic plasticity. The authors build upon their previous finding that DA applied after a timing pattern that ordinarily induces ...