AMPK agonists, such as metformin and AICAR ... and biguanides exert cytotoxic effects in LKB-1 deficient cells. The authors conclude by emphasizing the need to explore the context-specific ...

Metformin (LKB/AMPK inhibitor) induced autophagy contributed to cell death in T-ALL cells. Using the anti-Bcl-2 drug obatoclax in GC-resistant T-ALL cell lines showed increased autophagy mediated by ...

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AMP-activated protein kinase (AMPK), as a key regulator of cellular energy metabolism, influences multiple pathological processes associated with MASLD. This review systematically summarizes the ...