Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

Macrophages are activated ... HLH in patients with sepsislike critical illness that does not respond to sepsis-directed therapy. In sepsis-associated HLH, treatment with anakinra, in addition ...

catecholamines may also exert some proinflammatory effects through the 2 aderenoreceptor on macrophages. Wang et al. decreased mortality from sepsis in mice, using nicotine to activate the ...

CD39 targeting therapies are emerging as a promising strategy for modulating immune responses in a range of diseases. CD39 serves as a vital ectonucleotidase that influences the purinergic signaling ...

Figure 1. Cross talks between DAMPs and NETs in sepsis. Sepsis or hypoxia activates immune reactive cells, including macrophages, and neutrophils. In bacterial sepsis, PAMPs interact with PRR on ...

The study shows that mitochondria do more than provide energy; they play an active role in modulating the immune response.

"Therapies aimed at improving mitochondrial activity could benefit inflammatory diseases such as inflammatory bowel disease, sepsis ... ETC function also controls macrophages, or specialized ...

Sepsis is a systemic inflammatory response syndrome (SIRS ... Taken together, this study indicates that propofol can significantly reduce the release of HMGB1 protein in mouse macrophages stimulated ...

Inc. today provided full-year Abecma® (idecabtagene vicleucel; ide-cel) sales results for 2024, in partnership with Bristol Myers Squibb (BMS). "We are pleased to see Abecma expansion in the third ...