Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

Design Flow cytometry, immunohistochemistry, confocal imaging and gene expression analyses determined the phenotype, functional/transcriptomic profile and tissue topography of MerTK+ ...

Because of the immaturity of the neonatal immunologic system, mortality rates remain unacceptably high. However, with some therapies aimed at improving the immunological status of the patient ...

Background: Sepsis is a challenging condition increasingly managed in medical wards, however literature and clinical evidence in this hospital setting are lacking. Methods: Using the computational ...

catecholamines may also exert some proinflammatory effects through the 2 aderenoreceptor on macrophages. Wang et al. decreased mortality from sepsis in mice, using nicotine to activate the ...

"We used several advanced research methods, such as single-cell RNA sequencing and spatial transcriptomics, to investigate the heterogeneity, locations, and functions of hepatic macrophages in ...

The work appears in the journal Immunity. Macrophages are specialized immune cells located in every tissue of the body, where they play crucial roles in maintaining tissue homeostasis, responding ...

This may worsen sepsis, Vijay Rathinam and colleagues in the UConn School of Medicine report in the Jan. 23 issue of Cell. Their findings could lead ...

"Therapies aimed at improving mitochondrial activity could benefit inflammatory diseases such as inflammatory bowel disease, sepsis ... ETC function also controls macrophages, or specialized ...

His condition deteriorated in hospital and he died on 7 December after eventually being diagnosed with sepsis. The Welsh Ambulance Service said poor ambulance response times were a symptom of ...