Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

Researchers at Brown University and Cincinnati Children’s found that suppressing opsin 3 in the brain of mice makes them eat ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

To switch on the cell death signal, just 15% of all CD95 receptors on the cell membrane need to bind in twos or threes around ...

By analyzing E. coli protein levels, scientists found a surplus of membrane shuttle proteins that may play a role in antibiotic resistance.

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

Researchers at the Center for Life Sciences at the Paul Scherrer Institute PSI have for the first time identified structural ...

A recently published paper in Science China Life Sciences reports an interdisciplinary study utilizing single-cell sequencing data analysis to identify GPCRs involved in the regulation of adipogenesis ...

EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced ...