Patients with ERBB2-positive breast cancer and CNS-only metastasis are at a high risk for CNS-related death but have longer overall survival than those with concomitant extracranial metastases.

A recent Tampa, Fla.-based Moffitt Cancer Center study found that up to 25% of patients with stage 4 breast cancer may develop asymptomatic brain metastasis. The study, published Jan. 24 in Neuro ...

However, the presence of intravascular tumor cells in the cerebral circulation does not always lead to the development of brain metastases. The development of brain metastases depends on the host ...

The three most common types of brain tumour are intracranial metastases, which spread from ... Phase II clinical trials have been completed in mesothelioma, ovarian cancer, NSCLC and pancreatic ...

“It's not that easy for cells to grow in the brain,” said Marsha Rosner, a cancer biologist at the University of Chicago. “They need some help.” Recent studies have shown that cancer cells secrete ...

Researchers have identified a key role microglia play in melanoma brain metastases progression and mechanisms to target them.

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers ...

pharmacodynamics and preliminary anti-tumor activity of ISM6331 as a single agent in patients with advanced or metastatic malignant mesothelioma or other solid tumors. The study consists of two ...

Melanoma is the most aggressive form of skin cancer and often spreads to the brain. Though immunotherapy has greatly improved the outlook for even metastatic melanoma patients, once melanoma brain ...

Novocure has ongoing clinical pipelines to treat brain metastases, NSCLC, ovarian cancer, pancreatic cancer, and mesothelioma. The preclinical R&D program includes breast cancer, cervical cancer ...