Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

A novel mechanism that enables cells to maintain energy production even when their main power supply drops/fails has been uncovered by biologists at Duke-NUS Medical School. In collaboration with an ...

For 1.5 billion years, the mitochondrial and nuclear genomes have been coevolving ... evolving compensatory mutations to maintain coadapted gene complexes. Researchers are now coming to appreciate ...

Mitochondrial DNA (mtDNA) is actively removed during spermatogenesis in a conserved process that enforces the uniparental ...

Analogous to chromosomal DNA that wraps around histone proteins to fit in the nucleus, mtDNA molecules are compacted into mtDNA-protein complexes termed nucleoids. Mitochondrial nucleoid proteins ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

Our lab studies the structure and function of mitochondrial membrane-shaping protein complexes in human parasites, and the bioenergetic role of mitochondrial energy-converting complexes in human ...

We study the molecular mechanism of proteins involved in biological energy conversion and mitochondrial function/dysfunction (respiratory complexes I-V). We apply multi-scale computational approaches ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...