When bred to ob/+ mice to induce metabolic stress, mice with myeloid cell-specific deletion of autophagy-related 7 (ATG7) displayed increased CLS numbers, activated NLRP3 inflammasome and IL-1β ...

It was observed to inhibit NLRP3 inflammasome activation by increasing autophagy ... Moreover, the integration of knowledge from extrahepatic signals (such as those from the gut and adipose tissue) ...

Although obese individuals are at greater risk of diabetes, high blood pressure or high cholesterol, not all obese people ...

Research has uncovered key differences in gene expression linked to inflammation, metabolism and cardioprotection. These findings could help inform the development of targeted therapies for ...

As many as 40% of Americans are obese, putting them at an increased risk for high blood pressure, diabetes, stroke, heart disease and certain cancers, according to the CDC.

Body weight and body mass index alone are not enough to predict whether someone will develop a metabolic disease. A new atlas of cells in fat tissue could help to explain why some overweight people ...

Time-restricted eating may not add additional benefit in visceral adipose tissue reduction over the Mediterranean diet for people with overweight or obesity.

RICHMOND, Calif., Jan. 28, 2025 (GLOBE NEWSWIRE) -- BioAge Labs, Inc. ("BioAge", “the Company”), a clinical-stage biopharmaceutical company developing therapeutic ...

Nomination of NLRP3 inhibitor BGE-102 as a development candidate, with initial Ph1 clinical data anticipated by end of 2025 Expansion of discovery efforts based on insights from BioAge’s ...