Nucleophilic substitution reactions remain a cornerstone of organic chemistry, offering a window into the fundamental aspects of reactivity and selectivity in molecular transformations.

The glycosylation reaction is central to complex carbohydrate synthesis, yet attaining complete stereocontrol remains challenging. During a glycosylation reaction, a glycosyl donor is activated to ...

The nucleophilic addition of several nucleophiles (allyltrimethylsilane, silyl enol ether from acetophenone, indole and N-sulfonylindole) to the enantiopure cyclic N-acyliminium ion 1a, derived from ...

Full conversion and enantioselectivities up to 83% have been obtained in the conjugate addition reactions of diethyl zinc to Michael acceptors catalyzed by well-defined (chiral) copper(I) ...