Active-comparator designs and new-user designs can help mitigate such biases in observational studies and improve the validity of their findings by making them more closely approximate RCTs.

Why register observational studies? Much of the rationale for the prospective registration of clinical trials 9 applies to the registration of observational studies (Table 1). 7 For example, ...

Why with observation alone there is no random assignment of exposure, so confounding by other factors should always be considered as an explanation for associations found in an observational study.

Incorporating the patient experience into observational studies can enhance the quality of real-world evidence gathered. Learn how patient-centred approaches can lead to stronger research outcomes.

“This large observational study looked at health records of over 26,000 people in the US diagnosed with chronic lower back pain and who were prescribed gabapentin within a 10-year period. They found ...

With careful attention to their design and analysis, observational database studies are powerful and modern tools for providing crucial data on drug effects.

This article presents a synthesis of potential benefits and drawbacks to relying on observational research to inform cancer care and makes a series of recommendations for enhancing its appropriate use ...

Prominent claims from observational studies of the cardiovascular benefits of vitamin E often continue to be supported in medical literature despite strong contradictory evidence from randomized ...

Knowledge of multiple linear regression and some familiarity with generalised linear models, to the level of MY452/MY552 or equivalent. Familiarity with notions of research design in the social ...

Why with observation alone there is no random assignment of exposure, so confounding by other factors should always be considered as an explanation for associations found in an observational study.