Pfizer Ltd has announced that the Scottish Medicines Consortium (SMC) has accepted Talzenna (talazoparib) in combination with ...

Two months after the last chemotherapy, Bianca Balti resumes her battle against cancer. Fresh from participating in the Milan ...

This enzyme is key to DNA repair in cells, so blocking it leads to cell death. Though PARP inhibitors are already approved to treat certain cancers, they come with toxicity risks thought to be ...

PARP inhibitors target the DDR PARP enzymes support single strand break repair and prevent formation of DNA double strand breaks (DSBs) during replication. Repair of these DSBs requires homologous ...

So they’re relying on less perfect forms of repair, like their PARP enzymes, to help them keep walking. PARP inhibitors are like taking away the crutches of someone with a broken leg. And ...

When a double strand of DNA is broken into a single strand, or damaged, PARP enzymes rush in to repair the damage so the cell can continue to grow and thrive. “PARPs are almost like repair trucks that ...