Intracellular kinases play a ubiquitous role in signaling pathways within cells ... nonreceptor tyrosine kinases and serine/threonine protein kinases function throughout cascades, phosphorylating ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine ... Activation of the phospholipase C-γ (PLCγ) pathway is also thought to contribute to NPM–ALK-mediated transformation.

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...