Satri-cel, a CLDN18.2-targeted CAR T-cell therapy, nearly doubles progression-free survival in patients with previously ...

When executed with precision and transparency, ECAs can enhance trial efficiency, expand access and support evidence—while ...

Background Pulmonary hypertension (PH) is a progressive cardiopulmonary condition associated with increased morbidity and ...

Introduction and aim Uncontrolled asthma is a global health challenge with substantial impact on quality of life (QoL) and overall healthcare costs. Unrecognised and/or unmanaged comorbidities often ...

Representativeness Of Pivotal Clinical Trials Disease burden information was available for 225 (232 drug-indication combinations) of the 290 drugs (appendix exhibit A3). 11 These 225 drugs ...

Therefore, a meta-analysis was conducted of randomized, double-blind, placebo-controlled, clinical outcome trials with SGLT2 inhibitors in people with type 2 diabetes at high cardiovascular risk or ...

Despite its potential efficacy in refractory cases, including those with neuronal surface antigen-mediated encephalitis,14–16 there is a lack of definitive randomised controlled trials assessing ...

Therefore, the aim of this trial is to evaluate the potential for sleep improvement using a dCBT programme, to improve rehabilitation outcomes after stroke. Methods and analysis We will conduct a ...

8,9 PEACE-1 is a randomized phase III trial that employed a 2x2 design to assess, separately and combined, the impact of the addition of abiraterone acetate/prednisone and radiation to standard of ...

Methods: A systematic review and network meta-analysis of randomized controlled trials (RCTs) were conducted in accordance with PRISMA guidelines. Data were sourced from PubMed, MEDLINE, Embase, Web ...

Methods Twenty-six recreationally active IDNA females were randomised to either an intravenous iron treatment ... Mood states and quality of life remained unchanged in both groups over the trial.