3D structure of the social amoeba genome sheds light on the transition to multicellularity
Each cell of the human body contains two meters of DNA. The whole secret lies in the intricate three-dimensional arrangement that allows DNA strands to be efficiently organized and compacted within ...
Dual mechanisms found to guard mitochondria against fusion-related damage
Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding ...
technologynetworks17d
How RNA Molecules Carry Instructions Across Many Generations
But while health care providers can now successfully develop drugs that use dsRNA to accurately target and silence disease-causing genes, a major challenge remains: getting these potentially ...
Frontiers19d
Single-cell transcriptomics: A new tool for studying diabetic kidney disease
Single-cell sequencing, including transcriptomics, epigenetics, metabolomics, and proteomics etc., is a powerful technology ... Compared with other omics, RNA sequencing is a more developed technique ...
gut.bmj19d
Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment
The glycolytic switch of TANs was validated by integrative multi-omics approach of transcriptomics, proteomics and metabolomics analysis ... Data are available in a public, open access repository.
gut.bmj19d
Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis
Design We performed single-cell RNA sequencing and spatial transcriptomic analysis in primary colorectal cancer (CRC) and metastases in the liver (lCRC) or ovary (oCRC). We also conducted ...
C&EN19d
Formaldehyde Fixation Helps Preserve the Proteome State during Single-Cell Proteomics Sample Processing and Analysis
Novo Nordisk Foundation Center for Protein Research, Proteomics Program, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark ...
Wired26d
Scientists Re-Create the Conditions That Sparked Complex Life
The original version of this story appeared in Quanta Magazine. Far from being solo operators, most single-celled microbes are in complex relationships. In the ocean, the soil, and your gut ...
YourTango27d
Psychology Says People With These 3 Personality Traits Are More Likely To Stay Single Forever
Statista reported that 62.18 million Americans were married in 2023. This is in contrast to the 117.6 million single Americans reported by the U.S. Census Bureau. Why so many people are choosing ...
Medscape27d
Proteomics Strategies to Analyze HPV-Transformed Cells: Relevance to Cervical Cancer
The progression of infected cells to the full neoplastic phenotype is fostered by a number of known and unknown factors. Proteomics strategies involved complementary tools for the characterization ...
Toronto Star28d
Single women are happier than single men, study finds. This could be why
Being single isn’t all that bad — and a study out of the University of Toronto suggests women might handle it better than men. In a paper published in December, lead author Elaine Hoan ...
Medical Xpress29d
Scientists uncover how cancer cells hijack T-cells, making it harder for the body to fight back
It essentially hacks the immune cells, transferring its own faulty mitochondrial DNA (mtDNA) into the T-cells meant to attack it. This sneaky move weakens the immune cells, making them less ...