Using α-syn fibril-induced PD model, researchers aimed to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain by the wireless DBS nanosystem. After stereotactic ...

Using an α-syn fibril-induced PD model, the researchers attempted to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain through use of the wireless DBS nanosystem.

MPP+ selectively kills dopaminergic neurons in pars compacta of the substantia nigra, inducing parkinsonian symptoms in ... It further indicates that the model generally captures motor symptoms more ...

Using an α-syn fibril-induced PD model, the researchers attempted to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain through the use of the wireless DBS nanosystem ...

Induced pluripotent stem cells (iPSCs), which greatly circumvent the ethical issue of human embryonic stem cells (ESCs), can be induced to differentiate to dopaminergic (DA) neurons, and hence be used ...

Reinforcement learning model. In the reinforcement learning model (from Frank ... Both processes originate in the striatum and receive cortical and subcortical inputs. SNc, substantia nigra pars ...

Hence, researchers often simulate the brain as a network of coupled neural masses, each described by a mean-field model. These models capture the essential features of neuronal populations while ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

But it does – and the Tesla Model 3 is the best known. It is, famously, a fully electric car – Tesla doesn’t do petrols, diesels or even hybrids – and it’s the US brand’s smallest and ...