Frontiers4d
Structure and function of the immunological and redirecting artificial synapses and their clinical implications
T cell receptor (TCR) and B cell receptor (BCR) stimulation by antigen on the surface of an antigen-presenting cell (APC) induces the formation of the immunological synapse (IS). The IS is a ...
Nature7h
Boosting CAR T-cell efficacy to increase cancer cure rates
1). “CO-CTEs are designed to organize co-stimulatory proteins around the binding site on the CAR to mimic the canonical T-cell immune synapse,” said Rennert. “By inducing immune synapse ...
pharmaphorum1d
Why the drug pricing debate is focused on insulin
The treatment has been around for over a century but insulin has still become the centre of the ongoing discussion over pricing of pharmaceutical products. Ben Hargreaves looks at why insulin’s ...
Medscape1d
Nanoengineering Approaches to the Design of Artificial Antigen-presenting Cells
Nanomedicine. 2013;8(7):1173-1189.