One candidate might be thymidine kinase 1 activity (TKa), expressed as a cell transverse through the cell cycle with high activity in proliferating cells. We determined TKa before and after adjuvant ...

Thymidine Kinase 2 Deficiency (TK2d) Guidelines Specific clinical guidelines for thymidine kinase 2 deficiency (TK2d) do not currently exist. However, physicians are encouraged to routinely assess ...

UCB, a global biopharmaceutical company, today announced positive data from studies involving its investigational pyrimidine nucleoside therapy, doxecitine (dC) and doxribtimine (dT), in people ...

Summary. 5-Iododeoxyuridine inhibited the utilization of radioactive orotic acid, formate, and thymidine for the biosynthesis of DNA-thymine, but not of orotic acid for the biosynthesis of ...

Summary. Methods for the synthesis of bromodeoxyuridine-Br82 and bromodeoxyuridine-H3 (BUdR) are described.The incorporation of both thymidine and BUdR into the deoxyribonucleic acid (DNA) of rat bone ...

We also found lower abundance and phosphorylation of myocardial AMPK (5′‐adenosine monophosphate‐activated protein kinase), indicating reduced AMPK activity in hearts after ibrutinib treatment.

Cyclic AMP (adenosine 3',5'-monophosphate or cyclic adenylate) has now been established as a second messenger mediating many of the effects of a variety of hormones. Several of the metabolic effects ...

Activation of AMPK Pathway in Methylene Blue-Induces Macroautophagy 5′ Adenosine monophosphate-activated protein kinase pathway has been characterized as another signal pathway that regulates ...