These efforts received a boost in 2011, when researchers led by Ryan Watts at Genentech, South San Francisco, California, reported using bispecific transferrin receptor (TfR)/β-secretase (BACE) ...

The binding of antibodies to cell surface receptors is performed at 4°C. Carrying out this step at this temperature blocks membrane tracking and thus, inhibits receptor endocytosis of the ...

In a recent study published in the journal Proceedings of the National Academy of Sciences, researchers demonstrated that human transferrin ... endocytosis. Notably, treatment with the anti-TfR ...