IgM is the first antibody to be produced in ... induced internalization of the receptor. Fcα/μR also mediated primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus.

The effectiveness of targeting chemotherapy-loaded NPs with EGFR antibodies has ... [179,180] Clathrin-mediated endocytosis ~200 nm Clathrin, actin, dynamin Transferrin, low-density lipoprotein ...

We further demonstrated that DVL proteins promote ligand-independent endocytosis of FZD but are dispensable for Wnt-induced FZD5/8 endocytosis and degradation. Our results reveal a novel negative ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

Monoclonal antibodies against P-cadherin can carry a drug payload to the cancer cells. It has not been clear, though, exactly how the antibodies attach to P-cadherin or how they get inside the ...

These are thyroperoxidase (TPO), thyroglobulin (Tg) and the TSH receptor. Other autoantigens ... in the neonate as a result of a mother with antibodies due to AITD. TPO antibodies (TPOAb) appear ...

The second presentation will highlight JCR’s lead product candidate, JR-141 (pabinafusp alfa, intravenous infusion), a recombinant fusion protein consisting of a humanized anti-transferrin receptor ...

Iron deficiency (ID) is currently defined as a serum ferritin level <100 or 100 to 299 ng/mL with transferrin saturation (TSAT ... We measured 4928 plasma proteins using an aptamer-based assay ...